Argireline is a trade name for a preparation of acetyl hexapeptide-3/8 developed and sold by the cosmetics firm Lipotec of Barcelona, Spain. For a time, Lipotec was very interested in what beauty products contain Argireline, as the company holds a patent on it and it’s the firm’s best-selling product.

Today, however, many other skincare product manufacturers include Argireline in their anti-wrinkle products. As a peptide-based skincare product, Argireline is a natural, mild protein derivative proven to be effective at relatively low levels. It is not hard to find out what beauty products contain Argireline, since manufacturers focus strongly on this active ingredient.

Product details

The Lipotec website explains that Argireline is specifically considered a “cosmetic alternative to Botulinum Toxin A,” the preparation sold under the trade name Botox. Therefore, it is positioned as an anti-wrinkle treatment that works to reduce muscle contraction by interfering with the “receptors” in the facial muscles. When you make a list of what beauty products contain Argireline, you find these same claims of efficacy.

The formation of wrinkles, according to the research, may be delayed, prevented or reduced by relaxing the facial musculature. Clinical studies cited by Lipotec indicate that a diluted solution of Argireline (5-10%) applied over two- to four-week period “may provide an anti-wrinkle effect.” Interestingly, solutions under five percent and over ten were not shown to produce the same benefits. In considering what beauty products contain Argireline, it is important, therefore, to know the precise formulation.

Argireline is also shown to retard the release of catecholamine in what are known as “chromaffin cells,” since catecholamine buildup over a certain level may also contribute to wrinkles. Specifically, now, consumers are interested in what beauty products contain Argireline, so let’s take a look at the market.

Products using Argireline

Argireline is an ingredient in such skincare products as gels, serum preparations, cleaning/moisturizing agents and emulsions. Lipotec even markets it as both a powder and a five-percent solution for commercial use, but it is not available to consumers. It is listed, proudly in most cases, on the ingredient lists of many products.

So, what beauty products contain Argireline? Products from Reviva Labs, Janson Beckett and others contain varying amounts of the compound. Initially positioned as an alternative to Botox, Argireline -based products are also used for post-surgical programs, as they may extend some benefits gained from certain procedures.

What to use

Argireline is a widely distributed anti-wrinkle treatment with a record of success in a variety of product lines. The manufacturer, Lipotec, has no regulatory power over how its compound is used, however, so consumers already on the alert for what beauty products contain Argireline must take one more investigative step. They need to make sure that the products they choose are from established manufacturers with good reputations, using the correct and effective amount of the active ingredient.

There is more to skincare than the treatment of damage or attempts to reverse the effects of aging. Preventative measures are well known – avoiding overexposure to sunlight, using sunscreen, establishing a lifelong skincare regimen – and a balanced approach should be taken. At some point, however, you will most likely want to know what beauty products contain Argireline, and with the proper information ahead of time, you will be able to tell fact from fiction when it’s time to make your decisions.

Be sure to check on the other ingredients in Z Crème that make it a great anti aging and anti wrinkle cream. Argireline, SYN-AKE, Matrixyl 3000, Hyaluronic Acid and many other key ingredients make Z Crème the effective super cream that it is.

Argireline in Z Creme is a safe botox alternative for anti-aging looks with its anti-wrinkle efficacy. While there have been deaths and various paralysis of the face linked to botox treatments, the only side effects linked to Argireline are less wrinkles. Argireline is a safe topical applied to the skin and found in the best facial anti wrinkle creams. Unlike botox’s immediate effects Argireline takes weeks to work its anti-wrinkle anti-aging wonders – make no mistake Z Creme is an intensive wrinkle correcting cream for the eyes and whole face.

Description

The first hexapeptide that is a mimic of the N-terminal end of SNAP-25 which competes with this protein for a position in the SNARE complex. argireline® is an alternative to Botulinum Toxin, topically targeting the same wrinkle-formation mechanism in a very different way.

Properties

A unique anti-wrinkle peptide that has been shown in significant testing to be effective against the development of skin wrinkling, being a topical alternative to Botulinum Toxin A.

Science

One of the most striking signs of skin aging is increased wrinkling of the face. This can occur naturally over time and is identified by certain biochemical, histological and physiological changes that are amplified by environmental exposure and their secondary factors as the pull of gravity or repeated facial movements caused by the contraction of the muscles of facial expression. Muscles are contracted when they receive neurotransmitter release from inside a vesicle. argireline® mimics the N-terminal end of SNAP-25 and it competes with the natural protein for a position in the SNARE complex. If the SNARE complex is slightly destabilized, the vesicle can not release neurotransmitters efficiently and therefore muscle contraction is attenuated, preventing the formation of lines and wrinkles.

• Muscle contraction

The neurotransmitter in volved in muscle contraction is acetylcholine and it is released from a vesicle into the synapse. The SNARE protein complex is formed by three proteins: VAMP, Syntaxin and SNAP-25 and it is essential for neurotransmitter release at the synapsis and mediates the final steps of exocytosis. This complex is like a cellular hook that captures vesicles and brings them close to the membrane to enable their fusion.

• Botulinum Toxin A

Botulinum Toxin A paralyses the muscle by selectively blocking acetylcholine release at the neuromuscular junction. BoNT-A cleaves the protein SNAP-25 irreversibly, and therefore the SNARE complex cannot assemble. The nerve signal cannot be relayed, the muscle cannot contract and it is paralysed.

• argireline®

argireline® is a mimic of the N-terminal end of SNAP-25 and it competes with the natural protein for a position in the SNARE complex, so it destabilizes its formation, without breaking any of its components. If the SNARE complex is slightly destabilized, the vesicle cannot release neurotransmitters. As a consequence, muscle contraction is attenuated and the muscle is relaxed.

Z Crème uses Argireline and SYN-AKE (another safe botox alternative) as part of its anti-aging anti-wrinkle formula.

Argireline is a registered trademark by Barcelona-based research laboratory Lipotec.

Botox is a registered trademark of Allergan

Matrixyl 3000 is an anti-wrinkling and lifting effect ingredient that provides an anti-aging effect.  By definition Matrixyl 3000 contains two matrikines, Pal-GHK and Pal-GQPR which act in synergy to restore and maintain the skin’s youthful appearance.

Matrixyl 3000 properties are created by matrikines which are messengers of cutaneous restructuration and repair. They activate the neosynthesis of extracellular matrix macromecules providing Matrixyl 3000 with a visible ant-wrinkle efficacy.

Characteristics of Matrixyl 3000’s matrikines are that they are capable of regulating cell activities. They interact with specific receptors to activate certain genes involved in the process of extracellular matrix renewal and cell proliferation. With age these mechanisms become progressively weaker.

Clinical study in which 2 panels of 23 volunteers aged 39 to 74 applied a cream containing 3%

Matrixyl™3000 to their face against twice a day for 56 days. Anti-wrinkling and lifting efficacy was assessed by profilometry and photography.

MatrixylTM3000

Surface occupied by deep wrinkles (>200μm)   - 44.9%

Main wrinkle density   - 37.0%

Main wrinkle average depth   - 15.1%

Main wrinkle average volume   - 18.5%

Roughness   - 14.4%

Complexity (Lifting effect)   - 16.6

Tone   + 19.5%

Elasticity %

While products like arginerline relax skin to lessens wrinkles, Matrixyl 3000 rebuilds the collagen under the surface to lessen or eliminate wrinkles. Studies show that Matrixyl 3000 is an excellent anti-aging, face lifting and anti-wrinkle product.

A look into how Hyaluronic acid (HA) works to provide anti-aging and anti-wrinkle rejuvenation for the skin.

Here’s a brief overview of the role HA plays in one’s body:

HA holds water in the body.

HA acts as a lubricant in the heart valves.

HA is the spongy shock absorber at the ends of the bones.

HA holds most of the moisture in the skin.

HA makes up to 80% of the human eye.

HA provides a barrier against the spread of infection.

HA helps to erase fine facial aging lines and wrinkles.

HA produces scarless wound healing.

HA has antioxidant properties.

HA detoxifies the body.

HA provides form and shape to the body.

(above courtesy of Here & Now Books – How to Live 100 Years Without Growing Old by Bill Sardi

Hyaluronic acid (and its companion chondroitin sulfate) are forms of connective tissue that give form and substance to one’s body. HA does this by expanding the space around the cells by binding salt and water.  In between the individual cells is the connective tissue and collagen held together by theHA.

Z Crème helps both connective tissue and collagen rejuvenation with special ionized water and topical HA and Matrixyl 3000 to help create new collagen growth. This helps not only with younger looking skin but can reduce, repair or eliminate scars and stretch marks wrinkles hopefully without the use of expensive laser treatment.

The skin needs continual renewal due to its exposure to trauma, heat, pressure, solar radiation and other causes. HA plays a major role in skin renewal and in fact over half of all HA in the body is located in the skin itself.

Every 20 days the skin is renewing itself through the ages of 15-25 years. As we grow older this increases to approximately every 28 days.

72% of human skin is water. While HA is holding most of the water in – everyday about 4% is lost through the skin.  So as you get older there is a progressive loss of HA in one’s skin resulting in less water retention. Less HA & water means more wrinkles, less elasticity and a more aged look.

As a general rule the skin dermis of people over 60 have little to no HA. Contrast that to a baby’s skin which is loaded with HA.

Z Crème contains Hyaluronic Acid (HA) to help keep your skin looking moisturized and youthful. There is another way to help your skin and your whole body. The human body is constantly going through a stage of replacing the old with the new. To help keep the pace of the new up with the old consider taking Chondroitin Sulfate to your supplement program.

A special note is that chondroitin sulfate has been known to help thinning hair and even restore hair color by increasing HA levels in the body.

Chondroitin sulfate helps stimulate the production of Hyaluronic Acid in your body and is an excellent companion to Z Crème for helping your skin – and your whole body for that matter – retain its youth. For fast results for glowing skin and anti-aging anti-wrinkle Z Crème is the answer.

For thousands of years various cultures have used vitamin C through the use of various herbs to help with anti-aging and anti-wrinkle efforts. Back then they didn’t know the why like we do today.

Even if you take, ingest lots of vitamin C you still need a topical vitamin C for your skin. Most of the vitamin C that you take orally never makes it to your skin. Applying vitamin C topically is about 20 times more effective for skin care than same dose orally ingested. And once it’s absorbed into the skin – it’s in. Washing or jumping in the swimming pool isn’t going to take it away.

What’s really good about vitamin C and why it is used in Z Crème is its anti-aging and anti-wrinkle fighting effects. Around your late twenties your collagen synthesis slows down and begins a decline leading to wrinkles. Vitamin C helps boost collagen production with Z Crème other main collagen building ingredient Matrixyl 3000.

Vitamin C is also a very effective anti-oxidant fighting free radicals that can cause skin damage. Vitamin C can help improve skin tone, reduce roughness as well as the anti-wrinkling effect mentioned earlier. Vitamin C has also been known to help with acne and age spots (lentigines – dark spots on your skin.

Vitamin C also improves firmness and elasticity in the skin and helps retain water in your skins cells. This moisturizing effect also helps your skin have a brighter more youthful look.

Expensive European Cosmetic & Serums are no longer needed – Z Crème uses Vitamin C and other super ingredients to work in synergy to create an optimum anti-aging anti-wrinkle crème that rejuvenates your skin and gives it a youthful translucent glow.