What is Argireline and why it is a great anti-wrinkle treatment?

Argireline in Z Creme is a safe botox alternative for anti-aging looks with its anti-wrinkle efficacy. While there have been deaths and various paralysis of the face linked to botox treatments, the only side effects linked to Argireline are less wrinkles. Argireline is a safe topical applied to the skin and found in the best facial anti wrinkle creams. Unlike botox’s immediate effects Argireline takes weeks to work its anti-wrinkle anti-aging wonders – make no mistake Z Creme is an intensive wrinkle correcting cream for the eyes and whole face.

Description

The first hexapeptide that is a mimic of the N-terminal end of SNAP-25 which competes with this protein for a position in the SNARE complex. argireline® is an alternative to Botulinum Toxin, topically targeting the same wrinkle-formation mechanism in a very different way.

Properties

A unique anti-wrinkle peptide that has been shown in significant testing to be effective against the development of skin wrinkling, being a topical alternative to Botulinum Toxin A.

Science

One of the most striking signs of skin aging is increased wrinkling of the face. This can occur naturally over time and is identified by certain biochemical, histological and physiological changes that are amplified by environmental exposure and their secondary factors as the pull of gravity or repeated facial movements caused by the contraction of the muscles of facial expression. Muscles are contracted when they receive neurotransmitter release from inside a vesicle. argireline® mimics the N-terminal end of SNAP-25 and it competes with the natural protein for a position in the SNARE complex. If the SNARE complex is slightly destabilized, the vesicle can not release neurotransmitters efficiently and therefore muscle contraction is attenuated, preventing the formation of lines and wrinkles.

• Muscle contraction

The neurotransmitter in volved in muscle contraction is acetylcholine and it is released from a vesicle into the synapse. The SNARE protein complex is formed by three proteins: VAMP, Syntaxin and SNAP-25 and it is essential for neurotransmitter release at the synapsis and mediates the final steps of exocytosis. This complex is like a cellular hook that captures vesicles and brings them close to the membrane to enable their fusion.

• Botulinum Toxin A

Botulinum Toxin A paralyses the muscle by selectively blocking acetylcholine release at the neuromuscular junction. BoNT-A cleaves the protein SNAP-25 irreversibly, and therefore the SNARE complex cannot assemble. The nerve signal cannot be relayed, the muscle cannot contract and it is paralysed.

• argireline®

argireline® is a mimic of the N-terminal end of SNAP-25 and it competes with the natural protein for a position in the SNARE complex, so it destabilizes its formation, without breaking any of its components. If the SNARE complex is slightly destabilized, the vesicle cannot release neurotransmitters. As a consequence, muscle contraction is attenuated and the muscle is relaxed.

Z Crème uses Argireline and SYN-AKE (another safe botox alternative) as part of its anti-aging anti-wrinkle formula.

Argireline is a registered trademark by Barcelona-based research laboratory Lipotec.

Botox is a registered trademark of Allergan